People with SMD have a 2-3 times higher average mortality compared to the general population, which translates to a 10-20 year reduction in life expectancy . People with bipolar disorder and schizophrenia have been shown to have higher rates of mortality in both high and low-income settings. The majority of these premature deaths are due to physical health conditions.

Adolescence is a highly formative time for future health. While many of the challenges that emerge at this age are rooted in experiences in the womb or in young childhood, effects of the neurobiological changes in the very early years can emerge in adolescence. This will influence behaviours that can lead to heart disease and other chronic conditions that also tend to be established at this crucial time of life, including levels of physical activity, nutrition, tobacco smoking, and alcohol use.

•    Close to 800 000 people die due to suicide every year.
•    For every suicide there are many more people who attempt suicide every year. A prior suicide attempt is the single most important risk factor for suicide in the general population.
•    Suicide is the second leading cause of death among 15–29-year-olds.
•    79% of global suicides occur in low- and middle-income countries.
•    Ingestion of pesticide, hanging and firearms are among the most common methods of suicide globally.